In Silico Prediction of Indonesian Herbs Compounds as Covid-19 Supportive Therapy using Support Vector Machine

Many kinds of research on drug discovery using computational or in silico methods have been carried out. In this era of the Covid-19 pandemic, this research was also carried out by utilizing a commonly used technique, namely using machine learning to predict the interaction of compounds and proteins. This technique is known as Drug Target Interaction (DTI). The compounds used are herbal originating from Indonesia, and the protein used is a potential Covid-19 protein, one of which is SARS-CoV-2. The prediction process with machine learning can only be done on structured data. The data on herbal and protein were processed in this research using the Fingerprint as a descriptor compound and Pseudo Amino Acid Composition (PseAAC) as a protein descriptor technique. The result is structured data processed with the Support Vector Machine algorithm to create an interaction prediction model. The result is that the prediction accuracy is 95.96%. Furthermore, this model can predict Indonesian herbal compounds as drug candidates for Covid-19 supportive therapy. © 2021 IEEE.

The islamic perspective on the improvement of family economy in the new normal

This paper concerns with how to build a balance of rights and obligations of husband and wife in fulfilling the economic needs of the family, especially in unusual circumstances. The paper aims to give an overall picture of the authority of the husband and wife regarding the domestic and public rights in the family, as well as to deal with the issue on family economy during the Covid-19 pandemic. The study of this paper used the explorative-qualitative research methods, with data obtained by disseminating questionnaires and studying documents related to the responsibilities carried out by the husband and wife. An initial investigation was conducted by taking into account the provisions stipulated in the formal legality of positive law. The data were then analyzed by utilizing a descriptive phenomenological approach through the interpretation of the data obtained from observation, interview, documentation, and literature review. The findings of this study indicate that men and women have equal rights. The concept of nature show that there is normative justification between husband and wife, stating that the domestic responsibilities are closely related to the shared rights and obligations that are balanced within the family and society, and that both husband and wife have the same rights in taking legal actions. In this new normal era, to strengthen the economically weak family in the community requires joint co-operation between the husband and wife so that they can meet the needs of the family and create a harmonious family. © 2021 Samarah. All rights reserved.

HUMAN-NATURE INTERACTIONS THROUGH THE LENS OF GLOBAL PANDEMICS: A REVIEW

The frequency of pandemics occurrence has increased, from every 200 years in period before the 18th century, to occurring every 10 to 50 years in the last century. The illegal and unsustainable wildlife trade, the devastation of forests and other wild places, and rapid human mobility were the driving forces behind the increasing number of diseases leaping from wildlife to humans. This article analyzes present human-nature interactions during COVID-19 and projecting future interactions after the pandemic, based on review on academic literature and reports from international development organizations. We found that global pandemic such as COVID-19 is altering human-nature interactions in three major global ecological issues: wildlife, urban emission, and land use. For wildlife, COVID-19 affects human perception towards wildlife consumption and trade, as well as animal conservation. For land use, COVID-19 makes countries reduced efforts for forest monitoring and conservation. For urban emission, lockdown/mobility limitation and physical or social distancing policies are proven to some extent resulted in better human-nature interactions that reduce environmental problems. Reduced emission occurred from decreased industrial activities and mobilities. But this positive impact on environment may end once COVID-19 ends and human activities return to previous pattern. Therefore, structural change is required to prepare a resilient sustainable development by continuing existing positive human behavior during COVID-19 as a new normal of human-nature relationships. It is proven to reduce emission and if it is continued, it can have long term impacts on climate change mitigation.Alternate abstract:Частота возникновения пандемий в мире возрастает. Так, если до XVIII века пандемии возникали раз в 200 лет, то в XX веке они объявляются уже каждые 10-50 лет. Нерациональное и незаконное природопользование, уничтожение природных ландшафтов и высокая мобильность населения являются основными движущими силами увеличения у людей числа заболеваний, до того встречавшихся только у животных. Ð’ данной статье представлен анализ взаимодействий человека и окружающей среды во время пандемии COVID-19 с прогнозом на пост-пандемийный период на основании обзора научной литературы и отчетов международных организаций. Результат качественного синтеза информации позволяет предположить, что пандемии меняют взаимодействие человека и природы в трех основных доменах: дикая природа, выбросы вредных веществ и землепользование. Ð’ первом домене в пандемию меняется потребление и торговля объектами дикой природы. Ð’ период ограничения мобильности и экономической активности людей значительно снижается эмиссия вредных веществ промышленными предприятиями и транспортом в окружающую среду, что благоприятно сказывается на взаимоотношениях в системе человек - природа. Однако положительный эффект на окружающую среду завершится с завершением пандемии и возвращением человечества к прежнему уровню экономической °ÐºÑ‚ивности. Таким образом, опыт пандемий и связанные с ним изменения экономической и социальной активности человечества демонстрируют положительный эффект на окружающую среду и должны использоваться при планировании устойчивого развития в рамках новых взаимодействий человека и природы для уменьшения воздействий изменений климата на здоровье человека.